Tennessee State vs. Eastern Illinois prediction: Why Eastern Illinois is favored to win in college football Week 6, 2025

Eastern Illinois and Tennessee State will clash in Week 6 college football action at O'Brien Field on Saturday, starting at 3:00PM ET.

Based on updated simulations, Dimers' advanced college football model projects the Eastern Illinois as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Tennessee State vs. Eastern Illinois predictions page.

Tennessee State vs. Eastern Illinois prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Tennessee State vs. Eastern Illinois 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Eastern Illinois a 59% chance of beating Tennessee State. Our predicted final score has Eastern Illinois winning 26-23.

According to our model, Tennessee State (+6) has a 56% chance of covering the spread, while the 50.5-point over/under has an equal 50-50 chance of hitting.

Tennessee State vs. Eastern Illinois odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Tennessee State	Eastern Illinois
Spread	+6 (-110)	-6 (-110)
Moneyline	+180	-210
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Tennessee State vs. Eastern Illinois picks and best bets

Our model's biggest edge in today's Tennessee State vs. Eastern Illinois matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Tennessee State vs. Eastern Illinois game-day updates and essential details

Saturday's college football action between Eastern Illinois and Tennessee State at O'Brien Field is scheduled to begin at 3:00PM ET.

• Who: Tennessee State vs. Eastern Illinois
• Date: Saturday, October 4, 2025
• Time: 3:00PM ET/12:00PM PT
• Venue: O'Brien Field

Dimers' in-depth preview of Saturday's Tennessee State vs. Eastern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Tennessee State vs. Eastern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Eastern Illinois, with a 59% win probability, will likely beat Tennessee State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Tennessee State vs. Eastern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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