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Texas Southern vs. Southern University prediction: Texas Southern favored to win in college football Week 12, 2025

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Written by Mac Douglass

Get Texas Southern vs Southern University predictions for college football Saturday.

Texas Southern-Southern University Predictions and Game Preview.
Texas Southern vs. Southern University college football gameday prediction for Saturday, November 15, 2025.

Southern University and Texas Southern will lock horns in Week 12 college football action at A.W. Mumford Stadium on Saturday, starting at 3:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts Texas Southern as the most likely winner of the Texas Southern vs. Southern University game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Texas Southern vs. Southern University prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Texas Southern vs. Southern University 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Texas Southern a 63% chance of defeating Southern University. Our predicted final score has Texas Southern winning 28-23.

According to our model, Southern University (+7) has a 56% chance of covering the spread, while the over/under total of 52.5 points has an equal 50-50 chance of hitting.

 

Texas Southern vs. Southern University odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type Texas Southern Southern University
Spread -7 (-110) +7 (-110)
Moneyline -218 +200
Total o52.5 (-110) u52.5 (-105)

All odds are correct at the time of publication and are subject to change.

Texas Southern vs. Southern University picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Southern University +7 -110
Moneyline Southern University +200
Total Under 52.5 -105

According to our college football best bets, the top play to make on this game is Southern University to win.

 

Texas Southern vs. Southern University game-day updates and essential details

Saturday's college football game between Southern University and Texas Southern at A.W. Mumford Stadium is scheduled to commence at 3:00PM ET.

  • Who: Texas Southern vs. Southern University
  • Date: Saturday, November 15, 2025
  • Time: 3:00PM ET/12:00PM PT
  • Venue: A.W. Mumford Stadium

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To make the most of Saturday's enormous day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Texas Southern, with a 63% win probability, will likely beat Southern University on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Texas Southern vs. Southern University insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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