Blue Jays vs. Rays prediction: Why Tampa Bay is favored to win Tuesday's MLB matchup [9/16/2025]

MLB action continues on Tuesday at 7:35PM ET as the Toronto Blue Jays take on the Tampa Bay Rays at George M. Steinbrenner Field.

Ryan Pepiot (11-10, 3.59 ERA) will start on the mound for the Rays, while the Blue Jays are going with José Berríos (9-5, 3.99 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Rays as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Rays predictions page.

Rays vs. Blue Jays prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB game between the Blue Jays and Rays 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Rays a 52% chance of beating the Blue Jays.

According to our model, the 7.5-run over/under has a 58% chance of going over.

Blue Jays vs. Rays odds [9/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Rays
Moneyline	-106	-105
Total	o7.5 (-122)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Rays picks and best bets

Our model's biggest edge in today's Blue Jays vs. Rays matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Blue Jays vs. Rays game-day updates and essential details

Tuesday's MLB matchup between the Rays and Blue Jays at George M. Steinbrenner Field is scheduled to begin at 7:35PM ET.

• Who: Toronto Blue Jays vs. Tampa Bay Rays
• Date: Tuesday, September 16, 2025
• Time: 7:35PM ET/4:35PM PT
• Venue: George M. Steinbrenner Field

Dimers' full preview of Tuesday's Blue Jays vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rays, with a 52% win probability, will likely beat the Blue Jays on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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