Vanderbilt vs. Alabama prediction: Why Alabama is favored to win in college football Week 6, 2025

Alabama will face Vanderbilt in Week 6 college football action at Bryant-Denny Stadium on Saturday, with kickoff at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts the Alabama as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Vanderbilt vs. Alabama predictions page.

Vanderbilt vs. Alabama prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of Vanderbilt vs. Alabama 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Alabama a 77% chance of beating Vanderbilt. Our predicted final score has Alabama winning 34-22.

According to our model, Vanderbilt (+12.5) has a 51% chance of covering the spread, while the over/under total of 57.5 points has a 54% chance of going over.

Vanderbilt vs. Alabama odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Vanderbilt	Alabama
Spread	+12.5 (+102)	-12.5 (-110)
Moneyline	+400	-500
Total	o57.5 (-110)	u57.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Vanderbilt vs. Alabama picks and best bets

Our model's biggest edge in today's Vanderbilt vs. Alabama matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Vanderbilt vs. Alabama game-day updates and essential details

Saturday's college football matchup between Alabama and Vanderbilt at Bryant-Denny Stadium is scheduled to start at 3:30PM ET.

• Who: Vanderbilt vs. Alabama
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Bryant-Denny Stadium

Dimers' full preview of Saturday's Vanderbilt vs. Alabama matchup includes our prediction, picks and the latest betting odds.

Before making any Vanderbilt vs. Alabama picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Alabama, with a 77% win probability, will likely beat Vanderbilt on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Vanderbilt vs. Alabama insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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