Virginia vs. Louisville prediction: Louisville favored to win in college football Week 6, 2025

Louisville will face Virginia in Week 6 college football action at L&N Federal Credit Union Stadium on Saturday, commencing at 3:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Louisville as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Virginia vs. Louisville predictions page.

Virginia vs. Louisville prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Virginia vs. Louisville 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Louisville a 60% chance of beating Virginia. Our predicted final score has Louisville winning 31-27.

According to our model, Virginia (+6.5) has a 55% chance of covering the spread, while the over/under total of 59.5 points has a 55% chance of going over.

Virginia vs. Louisville odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Virginia	Louisville
Spread	+6.5 (-104)	-6.5 (-115)
Moneyline	+200	-250
Total	o59.5 (-106)	u59.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Virginia vs. Louisville picks and best bets

Our model's strongest edge in today's Virginia vs. Louisville matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Virginia vs. Louisville game-day updates and essential details

Saturday's college football action between Louisville and Virginia at L&N Federal Credit Union Stadium is scheduled to start at 3:30PM ET.

• Who: Virginia vs. Louisville
• Date: Saturday, October 4, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: L&N Federal Credit Union Stadium

Dimers' in-depth preview of Saturday's Virginia vs. Louisville matchup includes our prediction, picks and the latest betting odds.

Before making any Virginia vs. Louisville picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Louisville, with a 60% win probability, will likely beat Virginia on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Virginia vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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