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Wake Forest vs. Mississippi State prediction: Why Mississippi State is favored to win Duke's Mayo Bowl [2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Wake Forest vs Mississippi State predictions for college football Friday.
Mississippi State and Wake Forest will lock horns in the 2026 Duke's Mayo Bowl at Bank of America Stadium on Friday, starting at 8:00 PM ET.
Based on the latest simulation results, Dimers' advanced college football model predicts Mississippi State as the most likely winner of the Wake Forest vs. Mississippi State game.
This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.
Duke's Mayo Bowl prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of the 2026 Duke's Mayo Bowl 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Mississippi State a 58% chance of defeating Wake Forest. Our predicted final score has Mississippi State winning 28-25.
According to our model, Mississippi State (-3) has a 53% chance of covering the spread, while the over/under total of 51.5 points has an equal 50-50 chance of hitting.
Duke's Mayo Bowl odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Wake Forest | Mississippi State |
|---|---|---|
| Spread | +3 (-112) | -3 (-105) |
| Moneyline | +124 | -142 |
| Total | o51.5 (-125) | u51.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Wake Forest vs. Mississippi State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Mississippi State -3 | -105 |
| Moneyline | Mississippi State | -142 |
| Total | Under 51.5 | -105 |
According to our best college football bets, the top play to make on this game is Mississippi State -3 at the spread.
Wake Forest vs. Mississippi State game-day updates and essential details
Friday's college football game between Mississippi State and Wake Forest at Bank of America Stadium is scheduled to begin at 8:00 PM ET.
- Who: Wake Forest vs. Mississippi State
- Date: Friday, January 2, 2026
- Time: 8:00 PM ET/5:00PM PT
- Venue: Bank of America Stadium
Conclusion
We predict Mississippi State, with a 58% win probability, will likely beat Wake Forest on Friday.
AI and automation have enhanced this article to quickly deliver accurate Wake Forest vs. Mississippi State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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