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Nationals vs. Reds prediction: Why Cincinnati is favored to win Wednesday's MLB matchup [5/13/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Washington Nationals vs Cincinnati Reds predictions for MLB Wednesday.
MLB action continues on Wednesday at 6:40 PM ET as the Washington Nationals take on the Cincinnati Reds at Great American Ball Park.
Nick Lodolo (0-1, 6.75 ERA) will start for the Reds, up against Jake Irvin (1-4, 5.22 ERA) for the Nationals.
Based on updated simulations, Dimers' proven MLB model projects the Reds as the most likely winner of the Nationals vs. Reds game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Nationals vs. Reds prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Nationals and Reds, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Reds a 61% chance of beating the Nationals.
According to our model, the Nationals (+1.5) have a 55% chance of covering the run line, while the over/under total of nine runs has a 53% chance of going over.
Nationals vs. Reds odds [5/13/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Reds |
|---|---|---|
| Run Line | +1.5 (-140) | -1.5 (+126) |
| Moneyline | +140 | -158 |
| Total | o9 (-115) | u9 (-102) |
All odds are correct at the time of publication and are subject to change.
Nationals vs. Reds picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Reds -1.5 | +126 |
| Moneyline | Reds | -158 |
| Total | Over 9 | -115 |
According to our best MLB bets, the top play to make on this game is Reds -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Nationals vs. Reds game-day updates and essential details
Wednesday's MLB game between the Reds and Nationals at Great American Ball Park is scheduled to commence at 6:40 PM ET.
- Who: Washington Nationals vs. Cincinnati Reds
- Date: Wednesday, May 13, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 61% win probability, will likely beat the Nationals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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