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Women's March Madness picks today: Saturday's First Round best bets include North Carolina State vs. Michigan play [3/21/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get women's March Madness picks and NCAA Tournament best bets for Saturday, March 21, 2026.
Today’s women's March Madness picks for March 21, 2026 are here, with North Carolina State vs. Michigan and Syracuse vs. Iowa State among the First Round matchups identified as top value plays across Saturday’s women's NCAA Tournament schedule.
Dimers’ predictive analytics engine runs 24/7, scanning the latest women's basketball odds to unearth top betting edges throughout the bracket. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of women's March Madness picks today [3/21, updated 4:10PM ET]
Below, you’ll find today’s top women's March Madness bets, ranked by edge for Saturday, March 21, 2026.
North Carolina State ML (+920)
- Edge: 7.6%
- Probability: 17.4%
- Matchup: North Carolina State vs. Michigan (1:00PM ET, Sunday)
Our model has identified value on North Carolina State to defeat Michigan at +920 odds. A 17.4% probability produces an edge of 7.6%, making this the strongest play for today's First Round slate.
Syracuse ML (+245)
- Edge: 7.0%
- Probability: 36%
- Matchup: Syracuse vs. Iowa State (5:30PM ET, Saturday)
Syracuse ML carries a 7.0% edge and a probability of 36% at +245 odds, according to our model.
North Carolina ML (-128)
- Edge: 3.7%
- Probability: 59.8%
- Matchup: Maryland vs. North Carolina (12:00PM ET, Sunday)
North Carolina ML at -128 odds shows a 3.7% edge, supported by a 59.8% probability in simulations.
Illinois ML (-170)
- Edge: 2.9%
- Probability: 65.9%
- Matchup: Colorado vs. Illinois (9:30PM ET, Saturday)
A 2.9% edge and 65.9% probability make Illinois at the moneyline at a value play in the Colorado vs. Illinois matchup, per our model.
Syracuse vs. Iowa State over 149.5 points (-110)
- Edge: 2.9%
- Probability: 55.3%
- Matchup: Syracuse vs. Iowa State (5:30PM ET, Saturday)
Syracuse vs. Iowa State over 149.5 points at -110 odds presents a 2.9% edge, with simulations resulting in a probability of 55.3%.
Women's March Madness best bets summary: Saturday, 3/21/2026
As of 4:10PM ET, here are our top women's March Madness bets by edge:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| North Carolina State vs. Michigan | North Carolina State ML | +920 @ FanDuel | 7.6% | 17.4% |
| Syracuse vs. Iowa State | Syracuse ML | +245 @ DraftKings | 7.0% | 36% |
| Maryland vs. North Carolina | North Carolina ML | -128 @ FanDuel | 3.7% | 59.8% |
| Colorado vs. Illinois | Illinois ML | -170 @ FanDuel | 2.9% | 65.9% |
| Syracuse vs. Iowa State | Over 149.5 Points | -110 @ DraftKings | 2.9% | 55.3% |
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Conclusion
Today's women's March Madness best bets are locked and loaded for March 21, 2026, featuring plays such as North Carolina State ML and Syracuse ML. Powered by advanced simulations, these picks are here to boost your betting game.
All odds and probabilities in this article are correct and accurate at the time of publication.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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