Cardinals vs. Colts Preview and Prediction

Cardinals vs. Colts: Detailed Breakdown

Matchup Overview

• Teams: Cardinals vs. Colts
• Date: Sunday, October 12, 2025
• Time: 1:00 PM ET
• Venue: Lucas Oil Stadium
• NFL stats, rosters and injury reports

Current Betting Odds

• Spread: Colts favored at -7
• Total (Over/Under): 47.5
• Moneyline Odds: Cardinals +280, Colts -330

Dimers' Win Probabilities

• Cardinals: 28%
• Colts: 72%

Dimers.com's predictive NFL model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Projected Final Score

Our predicted final score for this NFL matchup is Cardinals 21-27 Colts.

This prediction is based on each team's average score and player stats following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cardinals a win probability of 28%, while the Colts have a win probability of 72%.

Summary

The Cardinals face off against the Colts in the NFL at Lucas Oil Stadium on Sunday, October 12, 2025. On this page, you'll find our preview, analysis and data-driven projections for the game.

Our Cardinals vs. Colts predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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