49ers vs. Buccaneers Preview and Prediction

49ers vs. Buccaneers: Detailed Breakdown

Matchup Overview

• Teams: 49ers vs. Buccaneers
• Date: Sunday, October 12, 2025
• Time: 4:25 PM ET
• Venue: Raymond James Stadium
• NFL stats, rosters and injury reports

Current Betting Odds

• Spread: Buccaneers favored at -3
• Total (Over/Under): 47.5
• Moneyline Odds: 49ers +140, Buccaneers -154

Dimers' Win Probabilities

• 49ers: 41%
• Buccaneers: 59%

Dimers.com's predictive NFL model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Projected Final Score

Our predicted final score for this NFL matchup is 49ers 22-25 Buccaneers.

This prediction is based on each team's average score and player stats following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives the 49ers a win probability of 41%, while the Buccaneers have a win probability of 59%.

Summary

The 49ers face off against the Buccaneers in the NFL at Raymond James Stadium on Sunday, October 12, 2025. On this page, you'll find our preview, analysis and data-driven projections for the game.

Our 49ers vs. Buccaneers predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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