Arizona Cardinals vs. Indianapolis Colts early prediction: Expert picks for NFL Week 6, 2025

The Arizona Cardinals and Indianapolis Colts will meet in Week 6 of the NFL season at Lucas Oil Stadium on Sunday, October 12, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cardinals vs. Colts predictions page.

Arizona vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cardinals vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cardinals 57%, Colts 43%
• Predicted final score: Cardinals 23-21 Colts
• Spread: Cardinals (-1.5) 50%, Colts (+1.5) 50%
• Total points (47.5): Over 44%, Under 56%

As of October 6, 2025, these Cardinals-Colts numbers and predictions reflect the latest data and insights available.

Cardinals vs. Colts Week 6 details

The NFL Week 6 game between the Colts and Cardinals at Lucas Oil Stadium is scheduled for October 12, 2025.

• Who: Arizona Cardinals vs. Indianapolis Colts
• Date: Sunday, October 12, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

Cardinals vs. Colts opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Cardinals -1.5 (-110), Colts +1.5 (-110)
• Moneyline: Cardinals -125, Colts +105
• Total: Over/Under 47.5 (-108/-112)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 6 betting promos and codes

Make the most of Dimers' Cardinals vs. Colts predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Cardinals, with a 57% win probability, will likely beat the Colts in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.