Red Sox vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [6/5/2026]
Get Boston Red Sox vs New York Yankees predictions for MLB Friday.

MLB action continues on Friday at 7:05 PM ET as the Boston Red Sox square off with the New York Yankees at Yankee Stadium.
Ryan Weathers (2-3, 3.52 ERA) will be the starting pitcher for the Yankees, while the Red Sox have opted for Sonny Gray (6-1, 3.06 ERA).
Based on updated simulations, Dimers' proven MLB model predicts the Yankees as the most likely winner of the Red Sox vs. Yankees game.
This article offers a closer look at Friday's matchup, including best bets and picks.
Red Sox vs. Yankees prediction: Who will win and cover?
Our famous predictive model gives the Yankees a 57.3% chance of defeating the Red Sox.
According to our model, the Red Sox (+1.5) have a 60.2% chance of covering the run line, while the over/under total of eight runs has a 56.2% chance of going over.
Red Sox vs. Yankees odds [6/5/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Red Sox | Yankees |
|---|---|---|
| Run Line | +1.5 (-172) | -1.5 (+145) |
| Moneyline | +122 | -144 |
| Total | o8 (-110) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Red Sox vs. Yankees picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +145 |
| Moneyline | Yankees | -144 |
| Total | Over 8 | -110 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Red Sox vs. Yankees game-day updates and essential details
Friday's MLB action between the Yankees and Red Sox at Yankee Stadium is scheduled to start at 7:05 PM ET.
- Who: Boston Red Sox vs. New York Yankees
- Date: Friday, June 5, 2026
- Time: 7:05 PM ET/4:05PM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 57.3% win probability, will likely beat the Red Sox in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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