Buffalo Bills vs. Atlanta Falcons early prediction: Expert picks for NFL Week 6, 2025

The Buffalo Bills and Atlanta Falcons will meet in Week 6 of the NFL season at Mercedes-Benz Stadium on Monday, October 13, 2025, starting at 7:15PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Falcons predictions page.

Buffalo vs. Atlanta early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Falcons game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 67%, Falcons 33%
• Predicted final score: Bills 26-21 Falcons
• Spread: Bills (-5.5) 46%, Falcons (+5.5) 54%
• Total points (48.5): Over 50%, Under 50%

As of October 5, 2025, these Bills-Falcons figures and predictions reflect the latest data and insights available.

Bills vs. Falcons Week 6 details

The NFL Week 6 game between the Falcons and Bills at Mercedes-Benz Stadium is scheduled for October 13, 2025.

• Who: Buffalo Bills vs. Atlanta Falcons
• Date: Monday, October 13, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Mercedes-Benz Stadium

Bills vs. Falcons opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Bills -5.5 (-110), Falcons +5.5 (-110)
• Moneyline: Bills -238, Falcons +195
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 67% win probability, will likely beat the Falcons in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Falcons matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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