CBB Parlay Picks for Sweet Sixteen March Madness games on Friday, March 27

The Sweet Sixteen round of the 2026 CBB Tournament wraps up today, Friday, March 27 with the first batch of games, and Dimers has teamed up with bet365 Sportsbook to bring you data-backed boosted CBB bets during each round of the tournament, from today's CBB parlay all the way through the National Championship in Indianapolis on April 6.

Dimers runs thousands of simulations for every CBB matchup, providing users with win probabilities, spread projections, college basketball player props, and total predictions for each game, so you're never flying blind, especially with the new Dimers App where you can unlock a free three-day trial of Dimers Pro today, giving you every single value bet across each day of the tournament.

For an example, see how we use the Dimers CBB player projections to find these four CBB player props to bet on today.

Tap the card below to get your three-day free trial today!
Get a three-day Dimers Pro free trial in the Dimers App!

How to find Dimers CBB bets in the Dimers App

Each day of the tournament, Dimers will identify the best betting value in each CBB tournament game, with our college basketball predictions covering the following markets:

• Moneyline predictions for every tournament game
• Against the spread (ATS) picks backed by simulation data
• Point total (over/under) projections
• Player props (points, rebounds, assists, and more)

Dimers Pros have complete access to daily predictions on the Dimers website and in the Dimers App, so don't miss out on your three-day free trial to give you insights across the tournament's opening rounds.

CBB Parlay Picks Today - Friday, March 27

We've selected these picks using a combination of Dimers CBB best bets and game predictions to find a combination of value and probability that gives us the best chance to win our CBB parlay.

Today's parlay targets two teams the Dimers model favors on the spread, with us taking them each to win their game, one favorite and one narrow underdog, boosting their odds with bet365.

CBB Parlay Bet: Michigan State to win

Game: Michigan State vs. UConn

Time: 9:45 PM ET

The Dimers model says don't sleep on the Spartans tonight.

Despite Connecticut entering as a slim 52% favorite, Michigan State brings a 55% probability to cover the +1.5 spread, and the math here is telling. To cover, the Spartans only need to win outright or lose by a single point, making a Michigan State victory the far more likely outcome of the two scenarios (lose by exactly 1 or win).

The engine driving this Spartan offense is point guard Jeremy Fears. He projects for 14.9 points and 9.5 assists in what figures to be a statement performance as they punch their ticket to the Elite Eight.

Meanwhile, Michigan State's frontcourt presents a matchup nightmare, as the Spartans rank first in limiting offensive rebounds defensively and ninth nationally in offensive rebound percentage, making second-chance opportunities against them nearly impossible to come by.

CBB Parlay Bet: Iowa State to win

Game: Iowa State vs. Tennessee

Time: 10:10 PM ET

Iowa State has a big question in this game around the availability of star Joshua Jefferson who was injured in their second round win.

Still, the Cyclones come in as a 4.5-point favorite with a 69% win probability, as well as a 52% probability to cover the 4.5 points per our model.

Even if their star can't go, the case presents itself against Tennessee who ranks 219th in turnovers nationally, and that's a costly habit against an Iowa State defense that forces on the fourth-most opponent possessions.

A look at our full tournament predictions reveals another big discrepancy: while Iowa State ranks with just a 5.8% probability to win the championship (fifth best), it's a stark contrast to Tennessee's 0.2%, which is dead last.

Boosted CBB Parlay Odds

Thanks to bet365 sportsbook, we get boosted odds on this CBB parlay, to raise it from odds of +220 to +245 for an even bigger payout.

Grab this boost at bet365 and good luck if tailing along today and for the rest of the tournament!

Our boosted CBB parlay at bet365 sportsbook, odds subject to change.

Dimers and responsible gambling

Please remember to enjoy gambling responsibly. Responsible gambling means setting limits, staying in control, and understanding that luck is just part of the game. Make informed choices, set a budget, and know when to take a break. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-MYRESET.