Michigan vs. Arizona prediction: Why Arizona is favored to win men's March Madness Final Four matchup [4/4/2026]

Men's college basketball action continues on Saturday at 8:54 PM ET as Michigan squares off with Arizona in Final Four action at Lucas Oil Stadium.

For this NCAA Tournament matchup, Michigan—the first Big Ten team in 50 years to go 10–0 on the road in conference play— face Arizona, a complete team with a monstrous frontcourt and NBA-level talent.

Based on the latest simulation results, Dimers' proven college basketball model predicts Arizona as the most likely winner of the Michigan vs. Arizona game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Michigan vs. Arizona prediction: Who will win and advance to the Championship Game?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAAM Tournament game between Michigan and Arizona, forming part of today's college basketball picks coverage.

Our famous predictive model currently gives Arizona a 55% chance of defeating Michigan. Our predicted final score has Arizona winning 79-78.

According to our model, Michigan (+1.5) has a 52% chance of covering the spread, while the 158.5-point over/under has an equal 50-50 chance of hitting.

Michigan vs. Arizona odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Michigan vs. Arizona picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: