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Charleston vs. USF prediction: South Florida favored to win men's college basketball matchup [12/10/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Charleston vs USF predictions for college basketball Wednesday.
Men's college basketball action continues on Wednesday at 7:00PM ET as Charleston locks horns with USF in men's college basketball action at Yuengling Center.
Based on the latest simulations, Dimers' proven college basketball model predicts South Florida as the most likely winner of the Charleston vs. USF game.
This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Charleston vs. USF prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Charleston and USF 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model gives South Florida an 87% chance of beating Charleston. Our predicted final score has South Florida winning 86-73.
According to our model, Charleston (+13.5) has a 53% chance of covering the spread, while the 160.5-point over/under has a 51% chance of staying under.
Charleston vs. USF odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Charleston | USF |
|---|---|---|
| Spread | +13.5 (-105) | -13.5 (-114) |
| Moneyline | +850 | -1100 |
| Total | o160.5 (-110) | u160.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Charleston vs. USF picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Charleston +13.5 | -105 |
| Moneyline | Charleston | +850 |
| Total | Under 160.5 | -108 |
According to our men's college basketball best bets, the top play to make on this game is Charleston to win.
Charleston vs. USF game-day updates and essential details
Wednesday's men's college basketball game between USF and Charleston at Yuengling Center is scheduled to commence at 7:00PM ET.
- Who: Charleston vs. South Florida
- Date: Wednesday, December 10, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Yuengling Center
Conclusion
We predict South Florida, with an 87% win probability, will likely beat Charleston on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Charleston vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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