Cubs vs. Brewers prediction: Why Milwaukee is favored to win Game 2 of NLDS [10/6/2025]

The Milwaukee Brewers will face the Chicago Cubs in Game 2 of the National League Division Series at American Family Field on Monday, starting at 9:08PM ET.

Aaron Ashby (0-0, 0.00 ERA in 2025 postseason) will be the starting pitcher for the Brewers, while the Cubs have opted for Shota Imanaga (0-0, 4.50 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Brewers as the most likely winner of today's game.

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Cubs vs. Brewers predictions page.

Cubs vs. Brewers prediction: Who will win Game 2?

Using innovative machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Cubs and Brewers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Brewers a 53% chance of beating the Cubs.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the over/under total of 7.5 runs has a 63% chance of going over.

Cubs vs. Brewers Game 2 odds [10/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Brewers
Run Line	+1.5 (-175)	-1.5 (+152)
Moneyline	+120	-136
Total	o7.5 (-110)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Brewers picks and best bets for Game 2

Our model's strongest edge in today's Cubs vs. Brewers matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Cubs vs. Brewers game-day updates and essential details

Monday's MLB action between the Brewers and Cubs at American Family Field is scheduled to begin at 9:08PM ET.

• Who: Chicago Cubs vs. Milwaukee Brewers
• Date: Monday, October 6, 2025
• Time: 9:08PM ET/6:08PM PT
• Venue: American Family Field

Dimers' full preview of Monday's Cubs vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Brewers, with a 53% win probability, will likely beat the Cubs on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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