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White Sox vs. Diamondbacks prediction: Why Arizona is favored to win Wednesday's MLB matchup [4/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago White Sox vs Arizona Diamondbacks predictions for MLB Wednesday.
The Arizona Diamondbacks will square off with the Chicago White Sox in MLB action at Chase Field on Wednesday, beginning at 9:40 PM ET.
The Diamondbacks will have Eduardo Rodriguez (1-0, 1.96 ERA) as their starting pitcher, pitting him against Anthony Kay (1-0, 2.60 ERA) for the White Sox.
Based on the latest simulation results, Dimers' advanced MLB model projects the Diamondbacks as the most likely winner of the White Sox vs. Diamondbacks game.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
White Sox vs. Diamondbacks prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the White Sox and Diamondbacks, forming part of our MLB predictions coverage.
Our independent predictive model gives the Diamondbacks a 60% chance of defeating the White Sox.
According to our model, the White Sox (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 56% chance of going over.
White Sox vs. Diamondbacks odds [4/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | White Sox | Diamondbacks |
|---|---|---|
| Run Line | +1.5 (-160) | -1.5 (+139) |
| Moneyline | +130 | -149 |
| Total | o9 (-105) | u9 (+100) |
All odds are correct at the time of publication and are subject to change.
White Sox vs. Diamondbacks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks -1.5 | +139 |
| Moneyline | Diamondbacks | -149 |
| Total | Over 9 | -105 |
According to our best MLB bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
White Sox vs. Diamondbacks game-day updates and essential details
Wednesday's MLB matchup between the Diamondbacks and White Sox at Chase Field is scheduled to start at 9:40 PM ET.
- Who: Chicago White Sox vs. Arizona Diamondbacks
- Date: Wednesday, April 22, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 60% win probability, will likely beat the White Sox in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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