Cavaliers vs. Pacers prediction: Cleveland to win, Donovan Mitchell projected for big game in Monday's NBA matchup [12/1/2025]

NBA action continues on Monday at 7:00PM ET as the Cleveland Cavaliers lock horns with the Indiana Pacers at Gainbridge Fieldhouse.

Based on the latest simulation results and today’s injury news, Dimers' advanced NBA model predicts the Cavaliers as the most likely winner of the Cavaliers vs. Pacers game.

This prediction follows the latest NBA Injury Report, which suggests the Pacers lineup will feature stars like Pascal Siakam, Bennedict Mathurin and Andrew Nembhard, while the Cavaliers will look to Donovan Mitchell, De'Andre Hunter and Evan Mobley.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Cavs vs. Pacers prediction: Who will win and cover?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Monday's clash between the Cavaliers and Pacers.

Our famous predictive model currently gives the Cavaliers a 66% chance of beating the Pacers. Our predicted final score has the Cavaliers winning 117-112.

According to our model, the Cavaliers (-4.5) have a 51% chance of covering the spread, while the over/under total of 230.5 points has a 51% chance of staying under.

Cavaliers vs. Pacers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Cavaliers vs. Pacers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Monday, the top play to make on this game is Cavaliers to win.

Cavaliers vs. Pacers player props

Betting on Cavaliers vs. Pacers NBA player props? We use the best information available to project how each team's leading players will perform at Gainbridge Fieldhouse.

Donovan Mitchell is expected to lead the Cavaliers with 27 points, 5 rebounds and 6 assists, while Pascal Siakam is projected to have 24 points, 7 rebounds and 5 assists for the Pacers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Cavaliers prediction

Our model's projected player stats for the Cavaliers are:

Pacers prediction

Projected points, rebounds, assists and three-pointers made for the Pacers:

Cavs vs. Pacers game-day updates and essential details

Monday's action between the Pacers and Cavaliers at Gainbridge Fieldhouse is scheduled to start at 7:00PM ET.

• Who: Cleveland Cavaliers vs. Indiana Pacers
• Date: Monday, December 1, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Gainbridge Fieldhouse

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Conclusion

We predict the Cavaliers, with a 66% win probability, will likely beat the Pacers on Monday, with Donovan Mitchell projected for a game-high 49 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Pacers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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