Dallas Cowboys vs. Carolina Panthers early prediction: Expert picks for NFL Week 6, 2025

The Dallas Cowboys and Carolina Panthers will meet in Week 6 of the NFL season at Bank of America Stadium on Sunday, October 12, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cowboys as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cowboys vs. Panthers predictions page.

Dallas vs. Carolina early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cowboys vs. Panthers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cowboys 58%, Panthers 42%
• Predicted final score: Cowboys 23-21 Panthers
• Spread: Cowboys (-1.5) 50%, Panthers (+1.5) 50%
• Total points (46.5): Over 44%, Under 56%

As of October 5, 2025, these Cowboys-Panthers numbers and predictions reflect the latest data and insights available.

Cowboys vs. Panthers Week 6 details

The NFL Week 6 action between the Panthers and Cowboys at Bank of America Stadium is scheduled for October 12, 2025.

• Who: Dallas Cowboys vs. Carolina Panthers
• Date: Sunday, October 12, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium

Cowboys vs. Panthers opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Cowboys -1.5 (-108), Panthers +1.5 (-112)
• Moneyline: Cowboys -125, Panthers +105
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cowboys, with a 58% win probability, will likely beat the Panthers in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cowboys vs. Panthers game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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