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Cowboys vs. Lions prediction: Detroit favored to win ‘TNF’ Week 14, 2025

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Written by Jason Bevilacqua

Get Dallas Cowboys vs Detroit Lions predictions for NFL Thursday.

Dallas Cowboys-Detroit Lions Predictions and Game Preview.
Dallas Cowboys vs. Detroit Lions NFL prediction for Thursday, December 4, 2025.

MISSOURI: Make the most of the recent MO sports betting launch with these Bet365 TNF odds boosts! With boosts available on Jahmyr Gibbs and Dak Prescott, it's a great way to start the weekend of football.

NFL Week 14 action continues on Thursday at 8:15PM ET as the Dallas Cowboys lock horns with the Detroit Lions at Ford Field.

Based on the latest simulations, Dimers' advanced NFL model predicts the Lions as the most likely winner of the Cowboys vs. Lions game.

This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Cowboys vs. Lions prediction: Who will win ‘Thursday Night Football’?

Since our Cowboys-Lions predictions earlier in the week, we have simulated the result of Thursday's NFL game between the Cowboys and Lions 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Lions a 61% chance of beating the Cowboys in Week 14 of the NFL season. Our predicted final score has the Lions winning 29-25.

According to our model, the bookies have got it right, and the Cowboys and Lions each have a 50% chance of covering the spread, while the over/under total of 55.5 points has a 53% chance of staying under.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 14 straight up picks.

Cowboys vs. Lions odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type Cowboys Lions
Spread +3.5 (-102) -3.5 (-102)
Moneyline +160 -186
Total o55.5 (-110) u55.5 (-108)

All odds are correct at the time of publication and are subject to change.

Cowboys vs. Lions picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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