DePaul vs. Butler prediction: Butler favored to win men's college basketball matchup [1/20/2026]

Butler and DePaul will meet in men's college basketball action at Hinkle Fieldhouse on Tuesday, with tipoff at 7:30 PM ET.

Based on updated simulations, Dimers' proven college basketball model projects Butler as the most likely winner of the DePaul vs. Butler game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

DePaul vs. Butler prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball matchup between DePaul and Butler 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Butler a 75% chance of defeating DePaul. Our predicted final score has Butler winning 79-72.

According to our model, DePaul (+7.5) has a 52% chance of covering the spread, while the 147.5-point over/under has a 55% chance of going over.

DePaul vs. Butler odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

DePaul vs. Butler picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: