Detroit Lions vs. Kansas City Chiefs early prediction: Expert picks for NFL Week 6, 2025

The Detroit Lions and Kansas City Chiefs will meet in Week 6 of the NFL season at GEHA Field at Arrowhead Stadium on Sunday, October 12, 2025, starting at 8:20PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chiefs as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. Chiefs predictions page.

Detroit vs. Kansas City early predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. Chiefs game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Lions 43%, Chiefs 57%
• Predicted final score: Lions 23-24 Chiefs
• Spread: Lions (+3) 58%, Chiefs (-3) 42%
• Total points (48.5): Over 45%, Under 55%

As of October 5, 2025, these Lions-Chiefs figures and predictions reflect the latest data and insights available.

Lions vs. Chiefs Week 6 details

The NFL Week 6 matchup between the Chiefs and Lions at GEHA Field at Arrowhead Stadium is scheduled for October 12, 2025.

• Who: Detroit Lions vs. Kansas City Chiefs
• Date: Sunday, October 12, 2025
• Time: 8:20PM ET/5:20PM PT
• Venue: GEHA Field at Arrowhead Stadium

Lions vs. Chiefs opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Lions +3 (-115), Chiefs -3 (-105)
• Moneyline: Lions +136, Chiefs -155
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 6 betting promos and codes

Make the most of Dimers' Lions vs. Chiefs predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Chiefs, with a 57% win probability, will likely beat the Lions in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. Chiefs matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.