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Tigers vs. Guardians prediction: Why Detroit is favored to win Game 1 of 2025 Wild Card Series
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB Wild Card predictions for MLB Tuesday.
The Cleveland Guardians will face the Detroit Tigers in Game 1 of their Wild Card Series at Progressive Field on Tuesday, starting at 1:08PM ET.
Gavin Williams (0-0, 0.00 ERA) will be the starting pitcher for the Guardians, while the Tigers are going with Cy Young hopeful Tarik Skubal (0-0, 0.00 ERA).
Based on the latest simulation results, Dimers' advanced MLB model predicts the Tigers as the most likely winner of today's game.
For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.
Guardians vs. Guardians prediction: Who will win, cover the run line?
Using trusted machine learning and data analysis, we have simulated the outcome of Tuesday's MLB matchup between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.
Our independent predictive model gives the Tigers a 60% chance of defeating the Guardians.
According to our model, the Guardians (+1.5) have a 54% chance of covering the run line, while the over/under total of 5.5 runs has a 69% chance of going over.
Tigers vs. Guardians odds [Wild Card Series Game 1]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Tigers | Guardians |
|---|---|---|
| Run Line | -1.5 (+115) | +1.5 (-132) |
| Moneyline | -168 | +145 |
| Total | o5.5 (-128) | u5.5 (-101) |
All odds are correct at the time of publication and are subject to change.
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Tigers vs. Guardians picks and best bets
Our model's strongest edge in today's Tigers vs. Guardians matchup is on the run line.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets
Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.
Tigers vs. Guardians game-day updates and essential details
Tuesday's MLB game between the Guardians and Tigers at Progressive Field is scheduled to start at 1:08PM ET.
- Who: Detroit Tigers vs. Cleveland Guardians
- Date: Tuesday, September 30, 2025
- Time: 1:08PM ET/10:08AM PT
- Venue: Progressive Field
Dimers' full preview of Tuesday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.
Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Tigers, with a 60% win probability, will likely beat the Guardians on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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