Tigers vs. Guardians prediction: Why Cleveland is favored to win Game 2 of 2025 Wild Card Series

The Cleveland Guardians and Detroit Tigers will lock horns in Game 2 of their Wild Card Series at Progressive Field on Wednesday, starting at 1:08PM ET.

The Guardians will have Tanner Bibee (0-0, 0.00 ERA) as their starting pitcher, while the Tigers will counter with Casey Mize (0-0, 0.00 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Tigers-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 54%, with the Tigers at 46%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.

Tigers vs. Guardians prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Guardians a 54% chance of defeating the Tigers.

According to our model, the Tigers (+1.5) have a 65% chance of covering the run line, while the over/under total of 7 runs has a 63% chance of going over.

Tigers vs. Guardians odds [Wild Card Series Game 2]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Guardians picks and best bets

Our model's strongest edge in today's Tigers vs. Guardians matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Tigers vs. Guardians game-day updates and essential details

Wednesday's MLB matchup between the Guardians and Tigers at Progressive Field is scheduled to begin at 1:08PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Wednesday, October 1, 2025
• Time: 1:08PM ET/10:08AM PT
• Venue: Progressive Field

Dimers' comprehensive preview of Wednesday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 54% win probability, will likely beat the Tigers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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