Los Angeles Chargers vs. Miami Dolphins early prediction: Expert picks for NFL Week 6, 2025

The Los Angeles Chargers and Miami Dolphins will meet in Week 6 of the NFL season at Hard Rock Stadium on Sunday, October 12, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chargers vs. Dolphins predictions page.

LA Chargers vs. Miami early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chargers vs. Dolphins game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chargers 58%, Dolphins 42%
• Predicted final score: Chargers 23-21 Dolphins
• Spread: Chargers (-2.5) 50%, Dolphins (+2.5) 50%
• Total points (45.5): Over 50%, Under 50%

As of October 6, 2025, these Chargers-Dolphins numbers and predictions reflect the latest data and insights available.

Chargers vs. Dolphins Week 6 details

The NFL Week 6 action between the Dolphins and Chargers at Hard Rock Stadium is scheduled for October 12, 2025.

• Who: Los Angeles Chargers vs. Miami Dolphins
• Date: Sunday, October 12, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Hard Rock Stadium

Chargers vs. Dolphins opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Chargers -2.5 (-112), Dolphins +2.5 (-108)
• Moneyline: Chargers -142, Dolphins +120
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 58% win probability, will likely beat the Dolphins in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Dolphins game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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