Dodgers vs. Giants prediction: Dodgers favored to win Wednesday's MLB matchup [4/22/2026]

MLB action continues on Wednesday at 9:45 PM ET as the Los Angeles Dodgers take on the San Francisco Giants at Oracle Park.

Tyler Mahle (0-3, 7.23 ERA) will start for the Giants, while the Dodgers have opted for Shohei Ohtani (2-0, 0.50 ERA).

Based on the latest simulation results, Dimers' advanced MLB model projects the Dodgers as the most likely winner of the Dodgers vs. Giants game.

This article offers a closer look at Wednesday's matchup, including best bets and picks.

Dodgers vs. Giants prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Dodgers and Giants, forming part of our MLB predictions coverage.

Our leading predictive model gives the Dodgers a 63% chance of beating the Giants.

According to our model, the Dodgers (-1.5) have a 51% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Dodgers vs. Giants odds [4/22/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Dodgers vs. Giants picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: