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Louisville vs. Indiana prediction: Why Louisville is favored to win men's college basketball matchup [12/6/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Louisville vs Indiana predictions for college basketball Saturday.
Indiana will face Louisville in men's college basketball action at Gainbridge Fieldhouse on Saturday, commencing at 2:15PM ET.
Based on updated simulation results, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Louisville vs. Indiana game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Louisville vs. Indiana prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Louisville and Indiana 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Louisville a 60% chance of defeating Indiana. Our predicted final score has Louisville winning 80-77.
According to our model, Indiana (+3.5) has a 56% chance of covering the spread, while the 161.5-point over/under has a 53% chance of staying under.
Louisville vs. Indiana odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisville | Indiana |
|---|---|---|
| Spread | -3.5 (-105) | +3.5 (-105) |
| Moneyline | -170 | +154 |
| Total | o161.5 (-115) | u161.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. Indiana picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Indiana +3.5 | -105 |
| Moneyline | Indiana | +154 |
| Total | Under 161.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Indiana +3.5 at the spread.
Louisville vs. Indiana game-day updates and essential details
Saturday's men's college basketball game between Indiana and Louisville at Gainbridge Fieldhouse is scheduled to start at 2:15PM ET.
- Who: Louisville vs. Indiana
- Date: Saturday, December 6, 2025
- Time: 2:15PM ET/11:15AM PT
- Venue: Gainbridge Fieldhouse
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Conclusion
We predict Louisville, with a 60% win probability, will likely beat Indiana on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Indiana insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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