Louisville vs. Pittsburgh prediction: Why Louisville is favored to win men's college basketball matchup [1/17/2026]

Men's college basketball action continues on Saturday at 8:00 PM ET as the favored Louisville locks horns with Pittsburgh in men's college basketball action at Petersen Events Center.

Based on the latest simulations, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Louisville vs. Pittsburgh game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. Pittsburgh prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball matchup between Louisville and Pittsburgh 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Louisville a 70% chance of beating Pittsburgh. Our predicted final score has Louisville winning 76-71.

According to our model, Pittsburgh (+7.5) has a 60% chance of covering the spread, while the 152.5-point over/under has a 54% chance of staying under.

Louisville vs. Pittsburgh odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Pittsburgh picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Pittsburgh +7.5 at the spread.

Louisville vs. Pittsburgh game-day updates and essential details

Saturday's men's college basketball action between Pittsburgh and Louisville at Petersen Events Center is scheduled to start at 8:00 PM ET.

• Who: Louisville vs. Pittsburgh
• Date: Saturday, January 17, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Petersen Events Center

Conclusion

We predict Louisville, with a 70% win probability, will likely beat Pittsburgh on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Pittsburgh insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.