Men's college basketball picks today: Friday's best bets include Quinnipiac vs. Iona play [12/5/2025]

Quinnipiac +3.5 (-115)

• Edge: 5.0%
• Probability: 58.4%
• Matchup: Quinnipiac vs. Iona (7:00PM ET, Friday)

Our model has identified value on Quinnipiac +3.5 at -115 odds. A 58.4% probability produces an edge of 5.0%, making this the strongest play for today's men's college basketball slate.

Kentucky +5.5 (-115)

• Edge: 4.6%
• Probability: 58%
• Matchup: Gonzaga vs. Kentucky (7:00PM ET, Friday)

Kentucky +5.5 carries a 4.6% edge and a probability of 58% at -115 odds, according to our model.

Niagara vs. Siena over 130.5 points (-105)

• Edge: 4.2%
• Probability: 55.5%
• Matchup: Niagara vs. Siena (7:00PM ET, Friday)

Niagara vs. Siena over 130.5 points at -105 odds shows a 4.2% edge, supported by a 55.5% probability in simulations.

Kentucky +5.5 (-115)

• Edge: 4.6%
• Probability: 58%
• Matchup: Gonzaga vs. Kentucky (7:00PM ET, Friday)

A 4.6% edge and 58% probability make Kentucky +5.5 vs. Gonzaga at a value play in the Gonzaga vs. Kentucky matchup, per our model.

Niagara vs. Siena over 130.5 points (-105)

• Edge: 4.2%
• Probability: 55.5%
• Matchup: Niagara vs. Siena (7:00PM ET, Friday)

Niagara vs. Siena over 130.5 points at -105 odds presents a 4.2% edge, with simulations resulting in a probability of 55.5%.

Michigan State -1.5 (+104)

• Edge: 3.1%
• Probability: 52.1%
• Matchup: Duke vs. Michigan State (12:00PM ET, Saturday)

Our model finds value on Michigan State -1.5 at +104 odds, supported by an edge of 3.1%.

Virginia Commonwealth -19.5 (-105)

• Edge: 2.9%
• Probability: 54.1%
• Matchup: Samford vs. Virginia Commonwealth (7:00PM ET, Friday) Our model has uncovered value on Virginia Commonwealth -19.5 at -105 odds. A 54.1% probability produces a 2.9% edge, making this a strong play for today's men's college basketball action.

San Jose State -6.5 (-120)

• Edge: 2.7%
• Probability: 57.3%
• Matchup: San Diego vs. San Jose State (10:00PM ET, Friday)

A 2.7% edge on a 57.3% probability makes San Jose State -6.5 at -120 odds a solid value play in today's San Diego vs. San Jose State matchup.

Bryant University +6.5 (-110)

• Edge: 2.7%
• Probability: 55%
• Matchup: Bryant University vs. Brown (7:00PM ET, Friday)

Our model projects value on Bryant University +6.5 at -110 odds. A 55% probability produces a 2.7% edge, making Bryant University the favorable side in Saturday’s matchup.

Marist ML (-500)

• Edge: 2.6%
• Probability: 86%
• Matchup: Mount St. Mary's vs. Marist (7:00PM ET, Friday)

Rounding out our top 10 bets, Marist to defeat Mount St. Mary's at -500 odds shows an 86% probability and a 2.6% edge.

NCAAM best bets summary: Friday, 12/5/2025

As of 2:01PM ET, here are our top men's college basketball bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Quinnipiac vs. Iona	Quinnipiac +3.5	-115 @ BetMGM	5.0%	58.4%
Gonzaga vs. Kentucky	Kentucky +5.5	-115 @ BetMGM	4.6%	58%
Niagara vs. Siena	Over 130.5 Points	-105 @ FanDuel	4.2%	55.5%
Gonzaga vs. Kentucky	Kentucky +5.5	-115 @ BetMGM	4.6%	58%
Niagara vs. Siena	Over 130.5 Points	-105 @ FanDuel	4.2%	55.5%
Duke vs. Michigan State	Michigan State -1.5	+104 @ FanDuel	3.1%	52.1%
Samford vs. Virginia Commonwealth	Virginia Commonwealth -19.5	-105 @ FanDuel	2.9%	54.1%
San Diego vs. San Jose State	San Jose State -6.5	-120 @ FanDuel	2.7%	57.3%
Bryant University vs. Brown	Bryant University +6.5	-110 @ BetMGM	2.7%	55%
Mount St. Mary's vs. Marist	Marist ML	-500 @ BetMGM	2.6%	86%

List of upcoming men's college basketball games to bet on now

• Niagara vs. Siena (7:00PM ET, Friday)
• Mount St. Mary's vs. Marist (7:00PM ET, Friday)
• Quinnipiac vs. Iona (7:00PM ET, Friday)
• South Alabama vs. East Tennessee State (7:00PM ET, Friday)
• Gonzaga vs. Kentucky (7:00PM ET, Friday)
• Canisius vs. St. Peter's (7:00PM ET, Friday)
• Fairfield vs. Manhattan (7:00PM ET, Friday)
• Samford vs. Virginia Commonwealth (7:00PM ET, Friday)
• Bryant University vs. Brown (7:00PM ET, Friday)
• South Carolina State vs. Bethune-Cookman (7:00PM ET, Friday)

Conclusion

Our men's college basketball best bets are locked and loaded for December 5, 2025, featuring plays such as Quinnipiac +3.5 and Kentucky +5.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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