March Madness picks today: Saturday's Second Round men's best bets highlight St. John's vs. Kansas play [3/21/2026]

Today’s men's March Madness picks for March 21, 2026 are here, with St. John's vs. Kansas among the Second Round matchups identified as top value plays across Saturday’s NCAA Tournament play.

Dimers’ predictive analytics engine runs 24/7, going over the latest men's college basketball odds to discover genuine betting edges throughout the bracket. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of men's March Madness picks tonight [3/21, updated 9:10PM ET]

Below, you’ll find today’s top men's March Madness bets, ranked by edge for Saturday, March 21, 2026.

Kansas +3.5 (-110)

• Edge: 6.0%
• Probability: 58.4%
• Matchup: St. John's vs. Kansas (5:15PM ET, Sunday)

Our model has identified value on Kansas +3.5 at -110 odds. A 58.4% probability produces an edge of 6.0%, making this the strongest play for today's Second Round slate.

List of upcoming Men's March Madness games to bet on now

• High Point vs. Arkansas (9:45PM ET, Saturday)
• Miami (FL) vs. Purdue (12:10PM ET, Sunday)
• Kentucky vs. Iowa State (2:45PM ET, Sunday)
• St. John's vs. Kansas (5:15PM ET, Sunday)
• Tennessee vs. Virginia (6:10PM ET, Sunday)
• Iowa vs. Florida (7:10PM ET, Sunday)
• Utah State vs. Arizona (7:50PM ET, Sunday)
• UCLA vs. Connecticut (8:45PM ET, Sunday)

College basketball betting and predictions promos for Saturday

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Conclusion

Today's men's March Madness best bets are locked and loaded for March 21, 2026, featuring plays such as Kansas +3.5. Powered by advanced simulations, these picks are here to boost your betting game.

All odds and probabilities in this article are correct and accurate at the time of publication.