Brewers vs. Cubs prediction: Why Cubs are favored to win Game 4 of NLDS [10/9/2025]

The Chicago Cubs will face the Milwaukee Brewers in Game 4 of the National League Division Series at Wrigley Field on Thursday, commencing at 9:08PM ET.

The Cubs will send Matthew Boyd (0-1, 5.40 ERA in 2025 postseason) to the mound, while the Brewers will counter with Cy Young hopeful Freddy Peralta (1-0, 3.18 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Brewers vs. Cubs predictions page.

Brewers vs. Cubs prediction: Who will win Game 4?

Using powerful machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the Brewers and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 52% chance of beating the Brewers.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the over/under total of 7 runs has a 65% chance of going over.

Brewers vs. Cubs Game 4 odds [10/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cubs
Run Line	-1.5 (+145)	+1.5 (-166)
Moneyline	-119	+104
Total	o7 (-120)	u7 (+100)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Cubs picks and best bets for Game 4

Our model's strongest edge in today's Brewers vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Brewers vs. Cubs game-day updates and essential details

Thursday's MLB action between the Cubs and Brewers at Wrigley Field is scheduled to start at 9:08PM ET.

• Who: Milwaukee Brewers vs. Chicago Cubs
• Date: Thursday, October 9, 2025
• Time: 9:08PM ET/6:08PM PT
• Venue: Wrigley Field

Dimers' comprehensive preview of Thursday's Brewers vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 52% win probability, will likely beat the Brewers on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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