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Twins vs. Mets prediction: Mets favored to win Wednesday's MLB matchup [4/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Minnesota Twins vs New York Mets predictions for MLB Wednesday.
The New York Mets will face the Minnesota Twins in MLB action at Citi Field on Wednesday, beginning at 7:10 PM ET.
The Mets will start Clay Holmes (2-2, 1.96 ERA), up against Connor Prielipp (0-0, 0.00 ERA) for the Twins.
Based on the latest simulation results, Dimers' proven MLB model predicts the Mets as the most likely winner of the Twins vs. Mets game.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
Twins vs. Mets prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Twins and Mets, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Mets a 59% chance of defeating the Twins.
According to our model, the Twins (+1.5) have a 60% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.
Twins vs. Mets odds [4/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Twins | Mets |
|---|---|---|
| Run Line | +1.5 (-162) | -1.5 (+141) |
| Moneyline | +140 | -160 |
| Total | o7.5 (-108) | u7.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Twins vs. Mets picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Mets -1.5 | +141 |
| Moneyline | Twins | +140 |
| Total | Over 7.5 | -108 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Twins vs. Mets game-day updates and essential details
Wednesday's MLB game between the Mets and Twins at Citi Field is scheduled to begin at 7:10 PM ET.
- Who: Minnesota Twins vs. New York Mets
- Date: Wednesday, April 22, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: Citi Field
Conclusion
We predict the Mets, with a 59% win probability, will likely beat the Twins in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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