MLB picks today: Wednesday's MLB best bets include Pirates vs. Rangers play [4/22/2026]

Pirates vs. Rangers over 8 runs (-108)

• Edge: 4.2%
• Probability: 56.1%
• Matchup: Pirates vs. Rangers (8:05PM ET, Wednesday)

Our model has identified value on over 8 runs in Pirates vs. Rangers at -108 odds. A 56.1% probability produces an edge of 4.2%, making this the strongest play for today's MLB slate.

White Sox vs. Diamondbacks over 9 runs (-102)

• Edge: 4.2%
• Probability: 54.7%
• Matchup: White Sox vs. Diamondbacks (9:40PM ET, Wednesday)

White Sox vs. Diamondbacks over 9 runs carries a 4.2% edge and a probability of 54.7% at -102 odds, according to our model.

Brewers vs. Tigers over 7.5 runs (-104)

• Edge: 2.7%
• Probability: 53.7%
• Matchup: Brewers vs. Tigers (6:40PM ET, Wednesday)

Brewers vs. Tigers over 7.5 runs at -104 odds shows a 2.7% edge, supported by a 53.7% probability in simulations.

Braves vs. Nationals over 9 runs (-105)

• Edge: 2.6%
• Probability: 53.8%
• Matchup: Braves vs. Nationals (6:45PM ET, Wednesday)

A 2.6% edge and 53.8% probability make Braves vs. Nationals over 9 runs at a value play in the Braves vs. Nationals matchup, per our model.

Orioles vs. Royals over 9 runs (-108)

• Edge: 2.5%
• Probability: 54.4%
• Matchup: Orioles vs. Royals (2:10PM ET, Wednesday)

Orioles vs. Royals over 9 runs at -108 odds presents a 2.5% edge, with simulations resulting in a probability of 54.4%.

Padres vs. Rockies over 12 runs (-106)

• Edge: 2.4%
• Probability: 53.8%
• Matchup: Padres vs. Rockies (8:40PM ET, Wednesday)

Our model finds value on over 12 runs in Padres vs. Rockies at -106 odds, supported by an edge of 2.4%.

Astros ML (+120)

• Edge: 2.3%
• Probability: 47.8%
• Matchup: Astros vs. Guardians (1:10PM ET, Wednesday)

Our model has uncovered value on Astros ML at +120 odds. A 47.8% probability produces a 2.3% edge, making this a strong play for today's MLB action.

Diamondbacks -1.5 (+135)

• Edge: 2.0%
• Probability: 44.6%
• Matchup: White Sox vs. Diamondbacks (9:40PM ET, Wednesday)

A 2.0% edge on a 44.6% probability makes Diamondbacks -1.5 at +135 odds a solid value play in today's White Sox vs. Diamondbacks matchup.

MLB best bets summary: Wednesday, 4/22/2026

As of 9:01AM ET, here are our top MLB bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Pirates vs. Rangers	Over 8 Runs	-108 @ DraftKings	4.2%	56.1%
White Sox vs. Diamondbacks	Over 9 Runs	-102 @ DraftKings	4.2%	54.7%
Brewers vs. Tigers	Over 7.5 Runs	-104 @ DraftKings	2.7%	53.7%
Braves vs. Nationals	Over 9 Runs	-105 @ BetMGM	2.6%	53.8%
Orioles vs. Royals	Over 9 Runs	-108 @ DraftKings	2.5%	54.4%
Padres vs. Rockies	Over 12 Runs	-106 @ DraftKings	2.4%	53.8%
Astros vs. Guardians	Astros ML	+120 @ BetMGM	2.3%	47.8%
White Sox vs. Diamondbacks	Diamondbacks -1.5	+135 @ BetMGM	2.0%	44.6%

List of upcoming MLB games to bet on [4/22/2026]

• Cardinals vs. Marlins (12:10PM ET, Wednesday)
• Astros vs. Guardians (1:10PM ET, Wednesday)
• Reds vs. Rays (1:10PM ET, Wednesday)
• Orioles vs. Royals (2:10PM ET, Wednesday)
• Blue Jays vs. Angels (3:07PM ET, Wednesday)
• Athletics vs. Mariners (4:10PM ET, Wednesday)
• Brewers vs. Tigers (6:40PM ET, Wednesday)
• Braves vs. Nationals (6:45PM ET, Wednesday)
• Yankees vs. Red Sox (6:45PM ET, Wednesday)
• Twins vs. Mets (7:10PM ET, Wednesday)
• Phillies vs. Cubs (7:40PM ET, Wednesday)
• Pirates vs. Rangers (8:05PM ET, Wednesday)
• Padres vs. Rockies (8:40PM ET, Wednesday)
• White Sox vs. D-Backs (9:40PM ET, Wednesday)
• Dodgers vs. Giants (9:45PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for April 22, 2026, featuring plays such as over 8 runs in the Pirates vs. Rangers matchup and over 9 runs in the White Sox vs. Diamondbacks matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.