New England Patriots vs. Buffalo Bills updated prediction featuring Rhamondre Stevenson, James Cook [Week 5, 2025]

Dimers' latest NFL predictions are live for Buffalo Bills and New England Patriots in Week 5, with our model giving the Bills a 77% of winning against the Patriots on Sunday.

This update builds on our early Bills-Patriots predictions, producing renewed win probabilities, score projections, and TD predictions for Rhamondre Stevenson, James Cook, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Patriots vs. Bills page.

What's changed? New England vs. Buffalo updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Patriots vs. Bills matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Patriots 23%, Bills 77%
• Predicted Final Score: Patriots 20-29 Bills
• Spread: Patriots (+8.5) 50%, Bills (-8.5) 50%
• Total Points (49.5): Over 50%, Under 50%

As of October 2, 2025, these Patriots-Bills calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 5 highlight the top candidates to find the end zone in Patriots-Bills on Sunday:

New England Patriots

• Rhamondre Stevenson: 31.1% probability
• TreVeyon Henderson: 29.3% probability
• Stefon Diggs: 27.1% probability

Buffalo Bills

• James Cook: 59.6% probability
• Josh Allen: 45.4% probability
• Keon Coleman: 29.3% probability

Patriots vs. Bills latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Patriots +8.5 (-112), Bills -8.5 (-105)
• Moneyline: Patriots +360, Bills -425
• Total: Over/Under 49.5 (-105/-108)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Patriots vs. Bills Week 5 details

The NFL Week 5 matchup between the Bills and Patriots at Highmark Stadium is scheduled for October 5, 2025.

• Who: New England Patriots vs. Buffalo Bills
• Date: Sunday, October 5, 2025
• Time: 8:20PM ET/5:20PM PT
• Venue: Highmark Stadium

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Conclusion

We predict the Bills, with a 77% win probability, will likely beat the Patriots in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Patriots vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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