Yankees vs. Red Sox prediction: Yankees favored to win Wednesday's MLB matchup [4/22/2026]

The Boston Red Sox will take on the New York Yankees, in what is expected to be a tight MLB game, at Fenway Park on Wednesday, beginning at 6:45 PM ET.

The Red Sox will send Ranger Suarez (1-1, 3.22 ERA) to the mound, pitting him against Max Fried (2-1, 2.97 ERA) for the Yankees.

Based on the latest simulation results, Dimers' advanced MLB model gives the Yankees a slight edge with a 52% win probability over the Red Sox.

This article offers further insights into Wednesday's Yankees vs. Red Sox matchup, including best bets and picks.

Yankees vs. Red Sox prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Yankees and Red Sox, forming part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 52% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has an equal 50-50 chance of hitting.

Yankees vs. Red Sox odds [4/22/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Yankees vs. Red Sox picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: