NFL picks straight up including Thanksgiving games: Week 13, 2025

At Dimers.com, we offer NFL picks straight up for Week 13 and beyond, as part of our extensive NFL picks and NFL predictions coverage.

With Week 13 of the NFL season here, we've used our dynamic predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Secure an advantage in your NFL pick 'em competitions via our data-driven NFL Week 13 picks straight up, powered by thousands of game simulations.

Week 13 of the NFL season features 16 games, starting with the Green Bay Packers facing the Detroit Lions on Thanksgiving and wrapping up with the New York Giants taking on the New England Patriots on Monday night.

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Full list of NFL Week 13 picks straight up

• Lions (58% win probability)
• Chiefs (59%)
• Ravens (70%)
• Eagles (74%)
• Jaguars (74%)
• Falcons (60%)
• Rams (82%)
• Dolphins (70%)
• Buccaneers (59%)
• 49ers (72%)
• Colts (68%)
• Seahawks (84%)
• Bills (60%)
• Chargers (81%)
• Broncos (68%)
• Patriots (74%)

NFL picks this week straight up: Week 13, 2025

Listed below are our Week 13 NFL picks, highlighting how likely each team is to win their game this week.

Green Bay Packers vs. Detroit Lions

The Packers kick off Week 13 against the Lions at Ford Field on Thanksgiving. According to our NFL model, the Lions have a 58% chance of winning, while the Packers have a 42% chance.

For Week 13's opening game, our model highlights NFL player props with Josh Jacobs (RB) as the most likely player from the Packers to score the first TD at 14.0%, while Jahmyr Gibbs (RB) is the top candidate from the Lions at 16.5%.

The Green Bay Packers vs. Detroit Lions game at Ford Field is scheduled for Thursday, November 27 at 1:00pm. All times stated in this article are in Eastern Standard Time (EST).

Kansas City Chiefs vs. Dallas Cowboys

For this week's game between the Chiefs and the Cowboys, Kansas City is more likely to win. Our prediction model gives the Chiefs a 59% chance of winning. On the other hand, there is a 41% chance that the Cowboys will win.

The Kansas City Chiefs vs. Dallas Cowboys matchup at AT&T Stadium will take place on Thursday, November 27 at 4:30pm.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Cincinnati Bengals vs. Baltimore Ravens

We are picking the Ravens to win their game against the Bengals this week, with our powerful NFL model projecting a 70% win probability for the home team. The Bengals have a 30% chance of winning at M&T Bank Stadium.

For betting purposes, the Ravens are listed as -7 favorites, with the Bengals' moneyline at +285.

The Cincinnati Bengals vs. Baltimore Ravens game at M&T Bank Stadium is slated for Thursday, November 27 at 8:20pm.

Chicago Bears vs. Philadelphia Eagles

According to our predictive analytics model, the Eagles are the team to beat in this game, with their win probability at 74%. The Bears, on the other hand, have a 26% chance of winning.

The Chicago Bears vs. Philadelphia Eagles game at Lincoln Financial Field is set for Friday, November 28 at 3:00pm.

Jacksonville Jaguars vs. Tennessee Titans

The Jaguars have a 74% chance of winning on Sunday afternoon, compared to the Titans' 26% chance of victory. This makes the Jacksonville Jaguars our pick to win at Nissan Stadium.

The Jacksonville Jaguars vs. Tennessee Titans matchup at Nissan Stadium is scheduled for Sunday, November 30 at 1:00pm.

Atlanta Falcons vs. New York Jets

The Falcons are favored to win here, with our predictive analytics model giving them a 60% chance, while the Jets enter the weekend with a 40% chance of winning at MetLife Stadium.

When it comes to betting on this game, the Falcons' moneyline odds are set at -140, with the home team Jets listed as +2.5 underdogs.

The Atlanta Falcons vs. New York Jets game at MetLife Stadium will take place on Sunday, November 30 at 1:00pm.

Los Angeles Rams vs. Carolina Panthers

After 10,000 simulations of Rams vs. Panthers this Sunday, our model projects the Rams as the more likely winners with a probability of 82%. Their opponents, the Panthers, have a 18% chance of getting the win at home.

The Los Angeles Rams vs. Carolina Panthers matchup at Bank of America Stadium is slated for Sunday, November 30 at 1:00pm.

New Orleans Saints vs. Miami Dolphins

DimersBOT is picking the Dolphins, who have a 70% chance of winning the matchup, while the Saints have a 30% win probability.

The New Orleans Saints vs. Miami Dolphins game at Hard Rock Stadium will take place on Sunday, November 30 at 1:00pm.

Arizona Cardinals vs. Tampa Bay Buccaneers

The next game of Week 13 sees the Cardinals take on the Buccaneers at Raymond James Stadium.

We predict the Buccaneers to win with a probability of 59%, while the Cardinals are projected to have a win chance of 41%.

As for the Vegas betting odds here, the Buccaneers are listed as -3 favorites, with the Cardinals' moneyline odds posted at +135.

The Arizona Cardinals vs. Tampa Bay Buccaneers game at Raymond James Stadium is scheduled for Sunday, November 30 at 1:00pm.

San Francisco 49ers vs. Cleveland Browns

The likely winner of this matchup is the 49ers, who have a projected win chance of 72%, according to DimersBOT. On the other side of this matchup, the Browns have a projected win probability of 28%.

The San Francisco 49ers vs. Cleveland Browns matchup at Huntington Bank Field is set for Sunday, November 30 at 1:00pm.

Houston Texans vs. Indianapolis Colts

We have run our powerful NFL model over this week’s Texans-Colts clash 10,000 times, with the Colts coming out as the team to pick. Of those 10,000 simulations, the Colts won 6,763 times, with the Texans winning on 3,237 occasions.

The Houston Texans vs. Indianapolis Colts game at Lucas Oil Stadium is scheduled for Sunday, November 30 at 1:00pm.

Minnesota Vikings vs. Seattle Seahawks

Next up is the game between the Vikings and Seahawks, with our model projecting the home team as the more likely victor, with the Seahawks rated as having a 84% chance of getting the W. The Vikings, on the other hand, are projected to have a 16% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Vikings' moneyline odds set at +500 for this road game, while the hosting Seahawks are listed as -10.5 favorites.

The Minnesota Vikings vs. Seattle Seahawks game at Lumen Field will take place on Sunday, November 30 at 4:05pm.

Buffalo Bills vs. Pittsburgh Steelers

Our next straight up pick this week is for the Bills to get the win against the Steelers. After running 10,000 simulations of this matchup, the Buffalo have a win probability of 60%, with the Steelers at 40%.

The Buffalo Bills vs. Pittsburgh Steelers game at Acrisure Stadium is slated for Sunday, November 30 at 4:25pm.

Las Vegas Raiders vs. Los Angeles Chargers

With a win probability of 81% on Sunday afternoon, our straight up pick for this matchup is the Chargers, while their opponent, the Raiders, have a projected win chance of 19%.

The Las Vegas Raiders vs. Los Angeles Chargers game at SoFi Stadium will take place on Sunday, November 30 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.

Denver Broncos vs. Washington Commanders

The team to pick here is the Broncos, who have a 68% chance of winning their matchup against the Commanders this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Commanders are listed as +6.5 underdogs at home, with the Broncos' moneyline odds available at -310.

The Denver Broncos vs. Washington Commanders game at Northwest Stadium is scheduled for Sunday, November 30 at 8:20pm.

New York Giants vs. New England Patriots

Our pick to win the final game of Week 13 is the Patriots, who have a win probability of 74%. Their opponents are projected to have a 26% chance of getting the W.

The New York Giants vs. New England Patriots game at Gillette Stadium is set for Monday, December 1 at 8:15pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 13

The NFL Week 13 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.