NFL Week 5 straight up picks: Expert predictions for every game [2025]

At Dimers.com, we provide NFL picks straight up for Week 5 and beyond, as part of our detailed NFL picks and NFL predictions coverage.

With Week 5 of the NFL season upon us, we've used our powerful predictive analytics model to deliver a list of NFL straight up picks for all 14 games this week.

Gain the edge in your NFL pick 'em contests with our data-driven NFL Week 5 picks straight up, powered by thousands of game simulations.

Week 5 of the NFL season features 14 games, starting with the San Francisco 49ers facing the Los Angeles Rams on Thursday night and ending with the Kansas City Chiefs taking on the Jacksonville Jaguars on Monday.

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NFL picks this week straight up: Week 5, 2025

Listed below are our Week 5 NFL picks, highlighting each team's chances of winning their game this week.

San Francisco 49ers vs. Los Angeles Rams

The 49ers kick off Week 5 against the Rams at SoFi Stadium on Thursday night. According to our NFL model, the Rams have a 69% chance of winning, while the 49ers have a 31% chance.

For Week 5's opening game, our model highlights NFL player props with Christian McCaffrey (RB) as the most likely player from the 49ers to score the first TD at 15.4%, while Kyren Williams (RB) is the top candidate from the Rams at 15.4%.

The San Francisco 49ers vs. Los Angeles Rams game at SoFi Stadium is scheduled for Thursday, October 2 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Minnesota Vikings vs. Cleveland Browns

For this week's game between the Vikings and the Browns, Minnesota is more likely to win. Our prediction model gives the Vikings a 63% chance of winning. On the other hand, there is a 37% chance that the Browns will pull off an upset win.

The Minnesota Vikings vs. Cleveland Browns matchup at Tottenham Hotspur Stadium will take place on Sunday, October 5 at 9:30am.

As the first week of byes hit, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Dallas Cowboys vs. New York Jets

We are picking the Cowboys to win their game against the Jets this week, with our famous NFL model projecting a 59% win probability for the road team. The Jets have a 41% chance of winning at MetLife Stadium.

For betting purposes, the Jets are listed as +2.5 underdogs, with the Cowboys' moneyline at -142.

The Dallas Cowboys vs. New York Jets game at MetLife Stadium is slated for Sunday, October 5 at 1:00pm.

Denver Broncos vs. Philadelphia Eagles

According to our predictive analytics model, the Eagles are the team to beat in this game, with their win probability at 67%. The Broncos, on the other hand, have a 33% chance of winning.

The Denver Broncos vs. Philadelphia Eagles game at Lincoln Financial Field is set for Sunday, October 5 at 1:00pm.

Houston Texans vs. Baltimore Ravens

The Texans have a 56% chance of winning on Sunday afternoon, compared to the Ravens' 44% chance of victory. This makes the Houston Texans our pick to win at M&T Bank Stadium.

The Houston Texans vs. Baltimore Ravens matchup at M&T Bank Stadium is scheduled for Sunday, October 5 at 1:00pm.

New York Giants vs. New Orleans Saints

The Saints are favorites to win their Week 5 matchup, with our predictive analytics model giving them a 54% chance, while the Giants enter the weekend with a 46% chance of winning at Caesars Superdome.

When it comes to betting on this game, the Giants' moneyline odds are set at +110, with the home team Saints listed as -2.5 favorites.

The New York Giants vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, October 5 at 1:00pm.

Las Vegas Raiders vs. Indianapolis Colts

After 10,000 simulations of Raiders vs. Colts this Sunday, our model projects the Colts as the more likely winners with a probability of 72%. Their opponents, the Raiders, have a 28% chance of getting the win on the road.

The Las Vegas Raiders vs. Indianapolis Colts matchup at Lucas Oil Stadium is slated for Sunday, October 5 at 1:00pm.

Miami Dolphins vs. Carolina Panthers

DimersBOT is picking the Dolphins, who have a 57% chance of winning the matchup, while the Panthers have a 43% win probability.

The Miami Dolphins vs. Carolina Panthers game at Bank of America Stadium will take place on Sunday, October 5 at 1:00pm.

Tampa Bay Buccaneers vs. Seattle Seahawks

The next game of Week 5 sees the Buccaneers take on the Seahawks at Lumen Field.

We predict the Seahawks to win with a probability of 61%, while the Buccaneers are projected to have a win chance of 39%.

As for the Vegas betting odds here, the Seahawks are listed as -3 favorites, with the Buccaneers' moneyline odds posted at +150.

The Tampa Bay Buccaneers vs. Seattle Seahawks game at Lumen Field is scheduled for Sunday, October 5 at 4:05pm.

Tennessee Titans vs. Arizona Cardinals

The likely winner of this matchup is the Cardinals, who have a projected win chance of 79%, according to DimersBOT. On the other side of this matchup, the Titans have a projected win probability of 21%.

The Tennessee Titans vs. Arizona Cardinals matchup at State Farm Stadium is set for Sunday, October 5 at 4:05pm.

Washington Commanders vs. Los Angeles Chargers

We have run our powerful NFL model over this week’s Commanders-Chargers clash 10,000 times, with the Chargers coming out as the team to pick. Of those 10,000 simulations, the Chargers won 6,022 times, with the Commanders winning on 3,978 occasions.

The Washington Commanders vs. Los Angeles Chargers game at SoFi Stadium is scheduled for Sunday, October 5 at 4:25pm.

Detroit Lions vs. Cincinnati Bengals

Next up is the game between the Lions and Bengals, with our model projecting the road team as the more likely victor, with the Lions rated as having a 79% chance of getting the W. The Bengals, on the other hand, are projected to have a 21% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Lions' moneyline odds set at -520 for this road game, while the hosting Bengals are listed as +10 underdogs.

The Detroit Lions vs. Cincinnati Bengals game at Paycor Stadium will take place on Sunday, October 5 at 4:25pm.

New England Patriots vs. Buffalo Bills

Our next straight up pick this week is for the Bills to get the win against the Patriots. After running 10,000 simulations of this matchup, the Buffalo have a win probability of 75%, with the Patriots at 25%.

The New England Patriots vs. Buffalo Bills game at Highmark Stadium is slated for Sunday, October 5 at 8:20pm.

Kansas City Chiefs vs. Jacksonville Jaguars

With a win probability of 60% on Monday night, our straight up pick for this game is the Chiefs, while their opponent, the Jaguars, have a projected win chance of 40%.

The Kansas City Chiefs vs. Jacksonville Jaguars game at EverBank Stadium will take place on Monday, October 6 at 8:15pm.

For a different angle on this week's NFL action, explore our NFL trends to find the latest player prop trends.

Full list of NFL Week 5 picks straight up

• Rams (69% win probability)
• Vikings (63%)
• Cowboys (59%)
• Eagles (67%)
• Texans (56%)
• Saints (54%)
• Colts (72%)
• Dolphins (57%)
• Seahawks (61%)
• Cardinals (79%)
• Chargers (60%)
• Lions (79%)
• Bills (75%)
• Chiefs (60%)

NFL straight up picks and predictions for Week 5

The NFL Week 5 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

If you decide to use our NFL straight up picks for betting, it's important to gamble responsibly and know when to stop. For more resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities mentioned on this page are subject to change.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast: