...
...
Read Article
Northwestern vs. DePaul prediction: Northwestern favored to win men's college basketball matchup [11/14/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Northwestern vs DePaul predictions for college basketball Friday.
Men's college basketball action continues on Friday at 8:30PM ET as the favored Northwestern locks horns with DePaul in men's college basketball action at Wintrust Arena.
Based on the latest simulation results, Dimers' proven college basketball model predicts Northwestern as the most likely winner of the Northwestern vs. DePaul game.
This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.
Northwestern vs. DePaul prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Friday's NCAA basketball matchup between Northwestern and DePaul 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Northwestern a 64% chance of beating DePaul. Our predicted final score has Northwestern winning 74-71.
According to our model, DePaul (+5.5) has a 61% chance of covering the spread, while the 145.5-point over/under has a 56% chance of going over.
Northwestern vs. DePaul odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Northwestern | DePaul |
|---|---|---|
| Spread | -5.5 (-102) | +5.5 (-118) |
| Moneyline | -225 | +200 |
| Total | o145.5 (-110) | u145.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Northwestern vs. DePaul picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +5.5 | -118 |
| Moneyline | DePaul | +200 |
| Total | Over 145.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is DePaul +5.5 at the spread.
Northwestern vs. DePaul game-day updates and essential details
Friday's men's college basketball game between DePaul and Northwestern at Wintrust Arena is scheduled to start at 8:30PM ET.
- Who: Northwestern vs. DePaul
- Date: Friday, November 14, 2025
- Time: 8:30PM ET/5:30PM PT
- Venue: Wintrust Arena
Conclusion
We predict Northwestern, with a 64% win probability, will likely beat DePaul on Friday.
AI and automation have enhanced this article to quickly deliver accurate Northwestern vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure