Oklahoma vs. South Carolina prediction: Oklahoma favored to win men's college basketball matchup [1/20/2026]

South Carolina will take on Oklahoma in men's college basketball action at Colonial Life Arena on Tuesday, beginning at 7:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model projects Oklahoma as the most likely winner of the Oklahoma vs. South Carolina game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Oklahoma vs. South Carolina prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's NCAA basketball matchup between Oklahoma and South Carolina 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Oklahoma a 62% chance of beating South Carolina. Our predicted final score has Oklahoma winning 77-74.

According to our model, Oklahoma (-2.5) has a 56% chance of covering the spread, while the over/under total of 150.5 points has a 53% chance of going over.

Oklahoma vs. South Carolina odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Oklahoma vs. South Carolina picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: