Parlay these Rams vs. 49ers player props at +450 odds for Thursday Night Football betting

It's Week 5 in the NFL and we're kicking things off with another Primetime Parlay built with the Dimers model for tonight's Los Angeles Rams vs. San Francisco 49ers Thursday Night Football matchup on October 2, 2025.

This is our biggest NFL season yet on Dimers, with the launch of our brand-new NFL Player Projections Hub, complete with boxscores and fantasy projections, our improved NFL models and the rollout of our new Dimers Sports Betting Podcast.

To kick off Week 5, we're using our model's Thursday Night Football predictions to build a +450 SGP over on DraftKings Sportsbook, where new users can claim a $200 sign-up bonus.

+450 Rams-49ers NFL Same Game Parlay Picks

After simulating tonight's game over 10,000 times, our model has identified the following projections and probabilities for the picks that make up our three-leg same game parlay in Rams vs. 49ers on Thursday Night Football, September 25.

MORE: Rams vs. 49ers TNF Full Game Betting Preview

Leg 1: Davante Adams 50+ Receiving Yards

First up is thew newest Rams WR, Davante Adams to do what he does best and rack up the yards.

Adams is over this mark in 4/4 games so far this season, thriving with his new team alongside OPOY favorite Puka Nacua and Matthew Stafford under center.

The veteran WR has racked up chunk plays in every game with long receptions of 24, 25, 33 and 44 yards this season, giving him the ability to knock out chunks of this line at a time.

The 49ers have a stout passing defense, but their pass rush has suffered in recent weeks after losing Nick Bosa, and it was on display vs. the Saints, letting multiple receivers hit this mark, and this Rams offense is far above the talent in New Orleans.

The Dimers model projects Adams for 61.3 receiving yards tonight, a healthy buffer of over 10 yards beyond the mark we need.

Leg 2: Christian McCaffrey 50+ Receiving Yards

Next up, we're looking at the only healthy star of the 49ers offense, Christian McCaffrey.

CMC has been plagued by injury issues in his career, yet while the 49ers around him are dropping like flies, he's workhorsing his way to a Comeback Player of the Year season.

Like Adams, CMC has hit this in all four of his games far, tallying as many as 70 receiving yards in 3 of 4, catching at least 6 passes in every game with 10+ targets in three - that's WR1 volume and the man is a running back.

With the entire 49ers WR corps banged up, expect Mac Jones to look for CMC underneath and when under pressure from the Rams front, ideally pushing him over the 50 yards mark with a projection of 54.0 from the Dimers model.

MORE: The Dimers Sports Betting Podcast

Leg 3: Puka Nacua Anytime TD Scorer

For our final leg, we'll close out as we almost always do with a top TD prop.

Our second-most likely TD scorer on the Rams and third overall in this game, Puka Nacua draws a 41.6% TD probability from the Dimers model.

He's scored twice this season, one one a reception and one on a big rushing play and if he wants to keep his hold on the OPOY race, he'll need to rack up some more scores.

Nacua is a perfect 3/3 on targets in the red zone, converting one into a score and has racked up over 100 yards in every game, with 15+ targets in his past two, hauling in 10 balls in 3/4 games - that type of elite volume and production gives him as much scoring upside as any player in the league.

RELATED: The best NFL prop bet in 49ers @ Rams on Thursday Night Football

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