Philadelphia Eagles vs. Buffalo Bills updated prediction featuring Saquon Barkley, James Cook [Week 17, 2025]

Dimers' latest NFL predictions are live for Buffalo Bills vs. Philadelphia Eagles in Week 17, with our model giving the Bills a 56% of winning.

As Sunday approaches, both teams have updated their injury reports. A few lineup decisions are still up in the air, and those could shape how each side approaches this cross-conference meeting.

Since our early Bills-Eagles predictions, we’ve updated the win probabilities, score projections, and TD odds for Saquon Barkley, James Cook, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—check out our Eagles vs. Bills page.

What's changed? Philadelphia vs. Buffalo updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Eagles vs. Bills matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Eagles 44%, Bills 56%
• Predicted Final Score: Eagles 21-23 Bills
• Spread: Eagles (+1.5) 50%, Bills (-1.5) 50%
• Total Points (43.5): Over 54%, Under 46%

As of December 25, 2025, these Eagles-Bills figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 17 highlight the top candidates to find the end zone in Eagles-Bills on Sunday:

Philadelphia Eagles

• Saquon Barkley: 47.9% probability
• Jalen Hurts: 43.2% probability
• A.J. Brown: 35.8% probability

Buffalo Bills

• James Cook: 49.3% probability
• Josh Allen: 40.8% probability
• Khalil Shakir: 26.8% probability

Eagles vs. Bills latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Eagles +1.5 (-112), Bills -1.5 (+100)
• Moneyline: Eagles -102, Bills -112
• Total: Over/Under 43.5 (-115/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Eagles vs. Bills Week 17 details

The NFL Week 17 action between the Bills and Eagles at Highmark Stadium is scheduled for December 28, 2025.

• Who: Philadelphia Eagles vs. Buffalo Bills
• Date: Sunday, December 28, 2025
• Time: 4:25 PM ET/1:25PM PT
• Venue: Highmark Stadium

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Conclusion

We predict the Bills, with a 56% win probability, will likely beat the Eagles in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Eagles vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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