Philadelphia Eagles vs. New York Giants early prediction: Expert picks for NFL Week 6, 2025

The Philadelphia Eagles and New York Giants will meet in Week 6 of the NFL season at MetLife Stadium on Thursday, October 9, 2025, starting at 8:15PM ET.

Initial simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Eagles vs. Giants predictions page.

Philadelphia vs. NY Giants early predictions

Leveraging trusted machine learning and analysis, we have simulated the Eagles vs. Giants game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Eagles 75%, Giants 25%
• Predicted final score: Eagles 24-18 Giants
• Spread: Eagles (-6.5) 54%, Giants (+6.5) 46%
• Total points (43.5): Over 46%, Under 54%

As of October 5, 2025, these Eagles-Giants numbers and predictions reflect the latest data and insights available.

Eagles vs. Giants Week 6 details

The NFL Week 6 matchup between the Giants and Eagles at MetLife Stadium is scheduled for October 9, 2025.

• Who: Philadelphia Eagles vs. New York Giants
• Date: Thursday, October 9, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: MetLife Stadium

Eagles vs. Giants opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: Eagles -6.5 (-115), Giants +6.5 (-105)
• Moneyline: Eagles -300, Giants +275
• Total: Over/Under 43.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Eagles, with a 75% win probability, will likely beat the Giants in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Eagles vs. Giants matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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