Portland vs. Seattle prediction: Seattle favored to win men's college basketball matchup [2/21/2026]

Seattle will square off with Portland in men's college basketball action at Redhawk Center on Saturday, starting at 10:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Seattle as the most likely winner of the Portland vs. Seattle game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Portland vs. Seattle prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball game between Portland and Seattle 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Seattle a 75% chance of defeating Portland. Our predicted final score has Seattle winning 75-68.

According to our model, Portland (+11.5) has a 62% chance of covering the spread, while the over/under total of 143.5 points has a 56% chance of going over.

Portland vs. Seattle odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Portland vs. Seattle picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Portland to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Portland vs. Seattle game-day updates and essential details

Saturday's men's college basketball matchup between Seattle and Portland at Redhawk Center is scheduled to begin at 10:00 PM ET.

• Who: Portland vs. Seattle
• Date: Saturday, February 21, 2026
• Time: 10:00 PM ET/7:00PM PT
• Venue: Redhawk Center

Conclusion

We predict Seattle, with a 75% win probability, will likely beat Portland on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Portland vs. Seattle insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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