Saint Louis vs. Duquesne prediction: Saint Louis favored to win men's college basketball matchup [1/20/2026]

Duquesne and Saint Louis are scheduled to meet in men's college basketball action at UPMC Cooper Fieldhouse on Tuesday, starting at 7:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model projects Saint Louis as the most likely winner of the Saint Louis vs. Duquesne game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Louis vs. Duquesne prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Tuesday's NCAA basketball matchup between Saint Louis and Duquesne 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Saint Louis a 75% chance of defeating Duquesne. Our predicted final score has Saint Louis winning 84-76.

According to our model, Duquesne (+9.5) has a 57% chance of covering the spread, while the over/under total of 164.5 points has a 54% chance of staying under.

Saint Louis vs. Duquesne odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Louis vs. Duquesne picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: