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Read Article Padres vs. Cubs prediction: Why Cubs are favored to win Monday's MLB matchup [6/29/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get San Diego Padres vs Chicago Cubs predictions for MLB Monday.
The Chicago Cubs will take on the San Diego Padres in MLB action at Wrigley Field on Monday, beginning at 8:05 PM ET.
Shota Imanaga (5-6, 4.40 ERA) will be the starting pitcher for the Cubs, pitting him against Griffin Canning (1-5, 7.38 ERA) for the Padres.
Based on the latest simulation results, Dimers' proven MLB model projects the Cubs as the most likely winner of the Padres vs. Cubs game.
This article offers a closer look at Monday's matchup, including best bets and picks.
Padres vs. Cubs prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Monday's MLB game between the Padres and Cubs, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Cubs a 57.8% chance of beating the Padres.
According to our model, the Padres (+1.5) have a 57.7% chance of covering the run line, while the 11.5-run over/under has a 52.8% chance of staying under,.
Padres vs. Cubs odds [6/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Padres | Cubs |
|---|---|---|
| Run Line | +1.5 (-138) | -1.5 (+122) |
| Moneyline | +135 | -158 |
| Total | o11.5 (+100) | u11.5 (-116) |
All odds are correct at the time of publication and are subject to change.
Padres vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Padres +1.5 | -138 |
| Moneyline | Padres | +135 |
| Total | Under 11.5 | -116 |
According to our best MLB bets, the top play to make on this game is Padres to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Padres vs. Cubs game-day updates and essential details
Monday's MLB action between the Cubs and Padres at Wrigley Field is scheduled to begin at 8:05 PM ET.
- Who: San Diego Padres vs. Chicago Cubs
- Date: Monday, June 29, 2026
- Time: 8:05 PM ET/5:05PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 57.8% win probability, will likely beat the Padres in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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