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Padres vs. Cubs prediction: Why Cubs are favored to win Game 1 of 2025 Wild Card Series
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB Wild Card predictions for MLB Tuesday.
The Chicago Cubs will square off with the San Diego Padres in Game 1 of their Wild Card Series at Wrigley Field on Tuesday, beginning at 3:08PM ET.
Matthew Boyd (0-0, 0.00 ERA) will start on the mound for the Cubs, while the Padres have opted for Nick Pivetta (0-0, 0.00 ERA).
Based on updated simulations, Dimers' proven MLB model predicts the Cubs as the most likely winner of today's game.
For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Cubs predictions page.
Cubs vs. Cubs prediction: Who will win, cover the run line?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB game between the Padres and Cubs 10,000 times as part of our MLB predictions coverage.
Our independent predictive model currently gives the Cubs a 55% chance of defeating the Padres.
According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the 6.5-run over/under has a 66% chance of going over.
Padres vs. Cubs odds [Wild Card Series Game 1]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Padres | Cubs |
|---|---|---|
| Run Line | +1.5 (-220) | -1.5 (+180) |
| Moneyline | +110 | -130 |
| Total | o6.5 (-114) | u6.5 (-105) |
All odds are correct at the time of publication and are subject to change.
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Padres vs. Cubs picks and best bets
Our model's biggest edge in today's Padres vs. Cubs matchup is on the run line.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets video
Calling Our Shot produces daily MLB betting content, including the free picks featured below.
Padres vs. Cubs game-day updates and essential details
Tuesday's MLB matchup between the Cubs and Padres at Wrigley Field is scheduled to start at 3:08PM ET.
- Who: San Diego Padres vs. Chicago Cubs
- Date: Tuesday, September 30, 2025
- Time: 3:08PM ET/12:08PM PT
- Venue: Wrigley Field
Dimers' comprehensive preview of Tuesday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.
Before making any Padres vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Cubs, with a 55% win probability, will likely beat the Padres on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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