San Francisco 49ers vs. Cleveland Browns updated prediction featuring Christian McCaffrey, Quinshon Judkins [Week 13, 2025]

Dimers' latest NFL predictions are live for Cleveland Browns vs. San Francisco 49ers in Week 13, with our model giving the 49ers a 72% of winning.

As Sunday approaches, both teams have updated their injury reports. A few lineup decisions are still up in the air, and those could shape how each side approaches this cross-conference clash.

Since our early Browns-49ers predictions, we’ve updated the win probabilities, score projections, and TD odds for Christian McCaffrey, Quinshon Judkins, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—check out our 49ers vs. Browns page.

What's changed? San Francisco vs. Cleveland updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Niners vs. Browns matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: 49ers 72%, Browns 28%
• Predicted Final Score: 49ers 21-16 Browns
• Spread: 49ers (-4.5) 54%, Browns (+4.5) 46%
• Total Points (36.5): Over 54%, Under 46%

As of November 27, 2025, these 49ers-Browns figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 13 highlight the top candidates to find the end zone in Niners-Browns on Sunday:

San Francisco 49ers

• Christian McCaffrey: 57.4% probability
• George Kittle: 34.6% probability
• Jauan Jennings: 29.3% probability

Cleveland Browns

• Quinshon Judkins: 42.6% probability
• Cedric Tillman: 20.3% probability
• Harold Fannin: 20.3% probability

Niners vs. Browns latest odds

The best current odds from the top sportsbooks in the US:

• Spread: 49ers -4.5 (-115), Browns +4.5 (-105)
• Moneyline: 49ers -235, Browns +220
• Total: Over/Under 36.5 (-106/-114)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Niners vs. Browns Week 13 details

The NFL Week 13 game between the Browns and 49ers at Huntington Bank Field is scheduled for November 30, 2025.

• Who: San Francisco 49ers vs. Cleveland Browns
• Date: Sunday, November 30, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Huntington Bank Field

NFL Week 13 betting promos and codes

Make the most of Dimers' 49ers vs. Browns predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the 49ers, with a 72% win probability, will likely beat the Browns in Week 13 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Browns game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.