49ers vs. Rams prediction: Rams favored to win TNF Week 5, 2025

NFL Week 5 action continues on Thursday at 8:15PM ET as the San Francisco 49ers take on the favored Los Angeles Rams at SoFi Stadium.

Based on updated simulation results, Dimers' advanced NFL model predicts the Rams as the most likely winner of today's game.

This gameday 49ers vs. Rams betting preview builds on my early 49ers vs. Rams prediction that was published earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Rams predictions page.

49ers vs. Rams Predictions

Since our 49ers-Rams predictions earlier in the week, we have simulated the outcome of Thursday's NFL game between the 49ers and Rams 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Rams a 76% chance of beating the 49ers in Week 5 of the NFL season. Our predicted final score has the Rams winning 25-18.

According to our model, the 49ers (+9) have a 56% chance of covering the spread, while the 43.5-point over/under has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 5 straight up picks.

49ers vs. Rams odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Rams
Spread	+9 (-125)	-9 (-105)
Moneyline	+350	-450
Total	o43.5 (-112)	u43.5 (-105)

All odds are correct at the time of publication and are subject to change.

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49ers vs. Rams picks and best bets

Our model's biggest edge in today's 49ers vs. Rams matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

49ers vs. Rams TD scorers

Who will score an anytime touchdown in 49ers vs. Rams?

According to our list of touchdown scorer predictions for TNF, Los Angeles' Kyren Williams is most likely to score the first touchdown in 49ers vs. Rams.

Our projections give Williams a 15.4% chance of getting in for six first at SoFi Stadium, while the Rams running back is a 54.1% chance of scoring an anytime touchdown.

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	14.6%
Kendrick Bourne (WR)	4.4%
Demarcus Robinson (WR)	4.2%

Los Angeles Rams

Player	First TD Probability
Kyren Williams (RB)	15.4%
Davante Adams (WR)	10.7%
Puka Nacua (WR)	10.6%

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	52.9%
Kendrick Bourne (WR)	20.3%
Demarcus Robinson (WR)	19.4%

Los Angeles Rams

Player	Anytime TD Probability
Kyren Williams (RB)	54.1%
Davante Adams (WR)	41.7%
Puka Nacua (WR)	41.5%

49ers vs Rams player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Rams. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 5 games.

49ers vs. Rams quarterbacks

Of the starting quarterbacks, the 49ers' Mac Jones is projected to throw for fewer yards than the Rams' Matthew Stafford.

49ers rushing

Christian McCaffrey, Brian Robinson and Mac Jones are projected to be the leading rushers for the 49ers.

Player	Position
Christian McCaffrey	RB
Brian Robinson	RB
Mac Jones	QB

Rams rushing

Kyren Williams, Blake Corum and Jordan Whittington are expected to lead the Rams in rushing yards.

Player	Position
Kyren Williams	RB
Blake Corum	RB
Jordan Whittington	WR

49ers receiving

Christian McCaffrey, Kendrick Bourne, Demarcus Robinson, Jake Tonges and Skyy Moore are projected to top the receiving yards for the 49ers.

Player	Position
Christian McCaffrey	RB
Kendrick Bourne	WR
Demarcus Robinson	WR
Jake Tonges	TE
Skyy Moore	WR

Rams receiving

Puka Nacua, Davante Adams, Jordan Whittington, Tutu Atwell and Colby Parkinson are projected to lead the Rams in receiving yards.

Player	Position
Puka Nacua	WR
Davante Adams	WR
Jordan Whittington	WR
Tutu Atwell	WR
Colby Parkinson	TE

Niners vs. Rams game-day updates and essential details

The NFL Week 5 action between the Rams and 49ers at SoFi Stadium is scheduled to commence at 8:15PM ET.

• Who: San Francisco 49ers vs. Los Angeles Rams
• Date: Thursday, October 2, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: SoFi Stadium

Dimers' comprehensive preview of this week's 49ers vs. Rams matchup includes our prediction, picks and the latest betting odds.

Before making any Niners vs. Rams picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rams, with a 76% win probability, will likely beat the 49ers in Week 5 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Rams insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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