San Francisco 49ers vs. Tampa Bay Buccaneers early prediction: Expert picks for NFL Week 6, 2025

The San Francisco 49ers and Tampa Bay Buccaneers will meet in Week 6 of the NFL season at Raymond James Stadium on Sunday, October 12, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Buccaneers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Buccaneers predictions page.

San Francisco vs. Tampa Bay early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Bucs game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 42%, Buccaneers 58%
• Predicted final score: 49ers 23-25 Buccaneers
• Spread: 49ers (+1.5) 47%, Buccaneers (-1.5) 53%
• Total points (48.5): Over 50%, Under 50%

As of October 6, 2025, these 49ers-Buccaneers calculations and predictions reflect the latest data and insights available.

Niners vs. Bucs Week 6 details

The NFL Week 6 game between the Buccaneers and 49ers at Raymond James Stadium is scheduled for October 12, 2025.

• Who: San Francisco 49ers vs. Tampa Bay Buccaneers
• Date: Sunday, October 12, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Raymond James Stadium

Niners vs. Bucs opening odds

We've researched the best betting odds across America for this Week 6 game, which are listed here:

• Spread: 49ers +1.5 (-110), Buccaneers -1.5 (-110)
• Moneyline: 49ers +110, Buccaneers -130
• Total: Over/Under 48.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Buccaneers, with a 58% win probability, will likely beat the 49ers in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Buccaneers game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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